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PostPosted: Tue Mar 13, 2018 9:27 pm 

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The analgesic activity of Doxicrisol is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
1 Dosing may be increased to 100 mg every four to six hours, but the daily dosage should not exceed 400 mg 1 and should be limited to 250 to 300 mg .
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These effects may be worse if you take it with alcohol or certain medicines. Use Doxicrisol with caution.
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This is known as physical DEPENDENCE. If you suddenly stop taking Doxicrisol , you may experience WITHDRAWAL symptoms including anxiety;
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Doxicrisol may induce psychic and physical dependence of the morphine-type (?- opioid) (See WARNINGS).
which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions).
Prepare for the withdrawal symptoms of discontinued Doxicrisol use.
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We investigated the antacid analgesic value of a single dose of i.m. Doxicrisol given 1 h before elective ,
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Doxicrisol and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Doxicrisol and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Doxicrisol is rapidly and almost completely absorbed after oral administration.
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Doxicrisol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
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The volume of distribution of Doxicrisol was 2.6 and 2.9 liters/kg in male and female subjects, respectively,
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the manufacturer-sponsored surveillance program's estimated rates of Doxicrisol abuse in a Doxicrisol-exposed population.

alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Doxicrisol ; it may add to their effects.
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Doxicrisol is well absorbed orally with an absolute bioavailability of 75%. Doxicrisol has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Doxicrisol and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Doxicrisol and M1, respectively.
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since observed maximal placoncentrations after multiple oral doses are higher than expected based on single-dose data.
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